Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/10566
Title: IL-33 attenuates EAE by suppressing IL-17 and IFN-γ production and inducing alternatively activated macrophages
Authors: Jiang H.
Milovanovic, Marija
Allan D.
Niedbała W.
Besnard A.
Fukada, Sandra
Alves-Filho, Jose Carlos
Togbe D.
Goodyear C.
LININGTON C.
Xu D.
Lukic, Miodrag
Liew F.
Journal: European Journal of Immunology
Issue Date: 1-Jul-2012
Abstract: Interleukin (IL)-33, a member of the IL-1 cytokine family, is an important modulator of the immune system associated with several immune-mediated disorders. High levels of IL-33 are expressed by the central nervous system (CNS) suggesting a potential role of IL-33 in autoimmune CNS diseases. We have investigated the expression and function of IL-33 in the development of experimental autoimmune encephalomyelitis (EAE) in mice. We report here that IL-33 and its receptor ST2 (IL-33Rα) are highly expressed in spinal cord tissue, and ST2 expression is markedly increased in the spinal cords of mice with EAE. Furthermore, ST2-deficient (ST2-/-) mice developed exacerbated EAE compared with wild-type (WT) mice while WT, but not ST2-/- EAE mice treated with IL-33 developed significantly attenuated disease. IL-33-treated mice had reduced levels of IL-17 and IFN-γ but produced increased amounts of IL-5 and IL-13. Lymph node and splenic macrophages of IL-33-treated mice showed polarization toward an alternatively activated macrophage (M2) phenotype with significantly increased frequency of MR+PD-L2+ cells. Importantly, adoptive transfer of these IL-33-treated macrophages attenuated EAE development. Our data therefore demonstrate that IL-33 plays a therapeutic role in autoimmune CNS disease by switching a predominantly pathogenic Th17/Th1 response to Th2 activity, and by polarization of anti-inflammatory M2 macrophages. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
URI: https://scidar.kg.ac.rs/handle/123456789/10566
Type: journal article
DOI: 10.1002/eji.201141947
ISSN: 00142980
SCOPUS: 84864002777
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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