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Title: Dipeptidyl peptidase-4 inhibitors as new tools for cardioprotection
Authors: Rankovic M.
Jeremic, Nevena
Srejovic, Ivan
Radonjic Katarina
Stojanovic, Aleksandar
Glisic M.
Bolevich, Stephani Sergeevna
Bolevich, Sergey
Jakovljevic, Vladimir
Issue Date: 2020
Abstract: © 2020, Springer Science+Business Media, LLC, part of Springer Nature. Previous studies have demonstrated that individuals with type 2 diabetes mellitus (T2DM) have a two- to fourfold propensity to develop cardiovascular disease (CVD) than nondiabetic population, making CVD a major cause of death and disability among people with T2DM. The present treatment options for management of diabetes propose the earlier and more frequent use of new antidiabetic drugs that could control hyperglycaemia and reduce the risk of cardiovascular events. Findings from basic and clinical studies pointed out DPP-4 inhibitors as potentially novel pharmacological tools for cardioprotection. There is a growing body of evidence suggesting that these drugs have ability to protect the heart against acute ischaemia-reperfusion injury as well as reduce the size of infarction. Consequently, the prevention of degradation of the incretin hormones by the use of DPP-4 inhibitors represents a new strategy in the treatment of patients with T2DM and reduction of CV events in these patients. Here, we discuss the cardioprotective effects of DPP-4 inhibitors as well as proposed pathways that these hypoglycaemic agents target in the cardiovascular system.
Type: review
DOI: 10.1007/s10741-020-10005-5
ISSN: 1382-4147
SCOPUS: 2-s2.0-85088306197
Appears in Collections:Faculty of Science, Kragujevac

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