Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/10727
Title: Correlation of Redox Status with Procalcitonin and C-reactive Protein in Septic Patients
Authors: Petrović J.
Nikolic Turnic T.
Zivkovic V.
Andjic M.
Draginic N.
Stojanovic, Aleksandar
Milinković I.
Bolevich, Sergey
Jevdjic, Jasna
Jakovljevic V.
Journal: Oxidative Medicine and Cellular Longevity
Issue Date: 1-Jan-2020
Abstract: © 2020 Jasna Petrovic et al. Based on the role of oxidative stress in the pathophysiological mechanisms of sepsis and the importance of PCT as a clinically applicable biomarker for early detection of inflammatory response initiation, we aimed this study at examining the correlation between PCT levels and oxidative stress parameters (prooxidants and antioxidants) in patients with sepsis. This study was designed as a case-series prospective clinical study which involved 103 critically ill patients and 17 healthy participants with diagnosis of sepsis/septic shock (over 18 years of age, both gender) admitted to the Intensive Care Unit (ICU) of Valjevo General Hospital in Serbia. All subjects were divided into patients who were operated on/underwent surgery before sampling and have sepsis (n=24), patients who were operated on/underwent surgery before sampling and have septic shock (n=25), patients who were not operated on/did not undergo surgery before sampling and have sepsis (n=26), patients who were not operated on/did not undergo surgery before sampling and have septic shock (n=28), and participants who are healthy (n=17). PCT has confirmed a positive correlation with prooxidants and type of critical illness, and performing surgical intervention diminished oxidative stress in patients with septic shock. Prognosis in critically ill patients was strongly associated with PCT levels but not with nonspecifically C-reactive protein.
URI: https://scidar.kg.ac.rs/handle/123456789/10727
Type: Article
DOI: 10.1155/2020/5147364
ISSN: 19420900
SCOPUS: 85091265572
Appears in Collections:Faculty of Medical Sciences, Kragujevac
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