Novel Platinum(II) Complexes Selectively Induced Apoptosis and Cell Cycle Arrest of Breast Cancer Cells In Vitro

Abstract

© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Two new dinuclear Pt(II) complexes with different aromatic nitrogen-containing heterocyclic compounds as the bridging ligands, [{Pt(en)Cl}2(μ-1,7-phen)](ClO4)2⋅H2O (C1) and [{Pt(en)Cl}2(μ-4,7-phen)](ClO4)2⋅H2O (C2), (1,7-phen and 4,7-phen are 1,7-phenanthroline and 4,7-phenanthroline while en is a bidentate coordinated ethylenediamine), were synthesized and structurally characterized by NMR (1H and 13C), IR and UV-vis spectroscopy. In vitro cytotoxic activity of these complexes was evaluated against two tumor cell lines, human breast carcinoma (MDA-MB-231) and mouse breast carcinoma cells (4T1), and against one type of healthy human fibroblasts cells (MRC-5). Platinum complex C1 showed stronger selectivity toward MDA-MB-231 and 4T1 breast carcinoma cells in comparison to cisplatin and oxaliplatin. Complex C2 displayed lower cytotoxicity than cisplatin and oxaliplatin in case of all stated cell lines, showing selectivity comparable to oxaliplatin.