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Title: Effects of different dietary regimes alone or in combination with standardized Aronia melanocarpa extract supplementation on lipid and fatty acids profiles in rats
Authors: Milić P.
Jeremic, Jovana
Zivkovic V.
Srejovic I.
Jeremić N.
Bradic, Jovana
Nikolic Turnic T.
Stojic, Isidora
Bolevich, Sergey
Bolevich, Sergey Brankovich
Labudovic-Borovic M.
Arsic, Aleksandra
Mitrovic M.
Jakovljevic V.
Vucic, Vesna
Issue Date: 2019
Abstract: © 2019, Springer Science+Business Media, LLC, part of Springer Nature. This study investigated different dietary strategies, high-fat (HFd), or standard diet (Sd) alone or in combination with standardized Aronia melanocarpa extract (SAE), as a polyphenol-rich diet, and their effects on lipids and fatty acids (FA) in rats with metabolic syndrome (MetS). Wistar albino rats were randomly divided into two groups: healthy and rats with MetS, and then depending on dietary patterns on six groups: healthy rats fed with Sd, healthy rats fed with Sd and SAE, rats with MetS fed with HFd, rats with MetS fed with HFd and SAE, rats with MetS fed with Sd, and rats with MetS fed with Sd and SAE. 4 weeks later, after an overnight fast (12–14 h), blood for determination of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), index of lipid peroxidation (measured as TBARS), and FA was collected. Increased FA and lipid concentration found in MetS rats were reduced when changing dietary habits from HFd to Sd with or without SAE consumption. Consumption of SAE slightly affects the FA profiles, mostly palmitoleic acid in healthy rats and PUFA in MetS + HFd rats. Nevertheless, in a high-fat diet, SAE supplementation significantly decreases n-6/n-3 ratio, thereby decreasing systemic inflammation. Further researches are warranted to confirm these effects in humans.
Type: article
DOI: 10.1007/s11010-019-03597-6
ISSN: 0300-8177
SCOPUS: 2-s2.0-85069898454
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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