Low-dimensional compounds containing bioactive ligands. Part XII: Synthesis, structures, spectra, in vitro antimicrobial and cytotoxic activities of zinc(II) complexes with halogen derivatives of quinolin-8-ol

Abstract

© 2019 Elsevier Ltd Seven new zinc(II) complexes, K[Zn(dClQ)3]·2DMF (1), K[Zn(dClQ)3]·2DMF·H2O (2), [Zn(dBrQ)2(H2O)]2·DMF·H2O (3), [Zn(BrQ)2(H2O)]2·H2O (4), (HdClQ)2[ZnCl4]·2H2O (5), [Zn(dClQ)2(H2O)2]·H2O (6) and [Zn(CQ)2(H2O)2] (7) (5,7-dichloroquinolin-8-ol (dClQ), protonated 5,7-dichloroquinolin-8-ol (HdClQ), 5,7-dibromoquinolin-8-ol (dBrQ), 7-bromoquinolin-8-ol (BrQ), 5-chloro-7-iodoquinolin-8-ol (CQ)) have been prepared. All complexes were characterized by IR spectroscopy, elemental analysis and, except 7, by X-ray structure analysis. Stability of complexes in dimethyl sulfoxide was verified by NMR spectra. Antimicrobial activity was tested against nine strains of pathogenic bacteria, five mould species and two yeast species. Cytotoxic activity was tested against colon cancer cell line HCT 116 and non-cancerous cell line CCD-18Co. While all complexes showed higher cytotoxicity than cisplatin, poor selectivity to normal cells was observed.