Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/10848
Title: Effects of selective serotonin reuptake inhibitors on motility of isolated fallopian tube
Authors: Milosavljević, Miloš
Jankovic R.
Jankovic, Slobodan
Djuric, Janko
Protrka, Zoran
Arsenijevic, Slobodan
Folic, Marko
Stojadinovic, Dobrivoje
Dimitrijevic, Aleksandra
Journal: Clinical and Experimental Pharmacology and Physiology
Issue Date: 1-Aug-2019
Abstract: © 2019 John Wiley & Sons Australia, Ltd Selective serotonin reuptake inhibitors (SSRIs) affect the smooth muscle cells acting on voltage-dependent channels for Na+, K+ and Ca2+, but their action is tissue and species specific. The aim of our study was to investigate effects of selective serotonin reuptake inhibitors on motility of the isolated fallopian tubes. Isolated preparations of isthmus and ampoule were taken from fallopian tubes of 20 women during hysterectomy due to uterine fibroids and then tested for reactivity on increasing concentrations of selective serotonin reuptake inhibitors. Escitalopram (from 0.9 × 10−9 M/L to 1.4 × 10−6 M/L) produced concentration-dependent increase of spontaneous contractions of the isolated ampulla (EC50 = 1.20 ± 1.06 × 10−8 M/L, r = 0.580, P < 0.05) (F = 2.980, df1 = 6, df2 = 28, P < 0.05). Paroxetine (from 1.2 × 10−9 M/L to 5.1 × 10−5 M/L) produced concentration-dependent increase of spontaneous contractions of the isolated isthmus (EC50 = 7.01 ± 3.50 × 10−8 M/L, r = 0.500, P < 0.05) (F = 2.350, df1 = 9, df2 = 40, P < 0.05). The SSRIs differ among themselves in regard to their potential to affect motility of the fallopian tubes. Escitalopram and paroxetine have clear stimulating effect which may interfere with functioning of the fallopian tubes, and potentially impair fertility if taken by women in reproductive period of life. The other SSRIs tested in the study did not produce significant effect throughout the concentration range used in the experiments.
URI: https://scidar.kg.ac.rs/handle/123456789/10848
Type: article
DOI: 10.1111/1440-1681.13118
ISSN: 03051870
SCOPUS: 85068081315
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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