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Title: Analysis on the risk factors for organ damage in patients with systemic lupus erythematosus: A cross-sectional single-center experience
Authors: Zivkovic V.
MitićII B.
Stamenković, Bojana
Stojanovic, Sonja K
Dinic B.
Stojanovic, Marijana
Jurisic, Vladimir
Issue Date: 2019
Abstract: © 2019 by Associação Paulista de Medicina. All Rights Reserved. BACKGROUND: Organ damage in patients with systemic lupus erythematosus (SLE) occurs as a consequence of the disease itself, the therapy applied and the accompanying conditions and complications. Organ damage predicts further organ damage and is associated with an increased risk of death. OBJECTIVE: This study aimed to assess the degree of irreversible organ changes in SLE patients, using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) damage index (SDI); to establish correlations between organ damage and disease activity, quality of life, intensity of fatigue and serological factors; and to ascertain the risk factors for organ damage. DESIGN AND SETTING: Cross-sectional single-center study conducted at the Institute for Treatment and Rehabilitation “Niška Banja”, Niš, Serbia. METHODS: 83 patients with SLE were enrolled: 58 patients formed the group with organ damage (SDI ≥ 1), and 25 patients without organ damage served as controls (SDI = 0). RESULTS: Organ damage correlated with age (P = 0.002), disease duration (P = 0.015), disease activity (grade 1, P = 0.014; and grade 2, P = 0.007), poor quality of life, severe fatigue (P = 0.047) and treatment with azathioprine (P = 0.037). The following factors were protective: use of hydroxychloroquine (P = 0.048) and higher scores obtained for the physical (P = 0.011), mental (P = 0.022) and general health (P = 0.008) domains. CONCLUSION: It is very important to evaluate risk factors for organ damage in the body, including physicians’ overall assessment, to try to positively influence better treatment outcomes.
Type: article
DOI: 10.1590/1516-3180.2018.0258060219
ISSN: 1516-3180
SCOPUS: 2-s2.0-85071340764
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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