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Title: Expression of PCNA, CD-31 and HER-2 in Serbian patients with oral squamous cell carcinoma
Authors: Loncarevic, Slobodan
Brajkovic D.
Gardasevic M.
Lončarević O.
Ladević N.
Nešić D.
Stamenković D.
Likić-Lađević I.
Ladević N.
Rancic, Nemanja
Journal: Archives of Biological Sciences
Issue Date: 1-Jan-2019
Abstract: © 2019 by the Serbian Biological Society. Several studies have investigated the expression of tumor markers, including p53, HER-2, PCNA, EGFR, VEGFR CD-31 and Bcl-2 in patients with oral squamous carcinoma (OSC). This study aimed to determine the expression of proliferating cell nuclear antigen (PCNA), endothelial functions of platelet/endothelial cell adhesion molecule-1 (CD31) and human epidermal growth factor receptor-2 (HER-2) according to OSC stage. The prospective study included 62 patients diagnosed with OSC stages II and III. Surgical specimens were obtained from tumor and peritumoral tissues. We determined the pathohistological degree of tumor differentiation and the immunohistochemical expression of PCNA, CD-31 and HER-2 for each specimen. Immunohistochemical analysis of the expression of PCNA in tumor cells demonstrated poor staining of immunoreactive tumor cells in 23 patients (10 in stage II, 7 in stage IIIa and 6 in stage IIIb). Moderately expressed PCNA-immunoreactivity in the tumor cells in 17 patients (7 in stage II, 6 in stage IIIa and 4 in stage III), and extremely strong PCNA-immunoreactive staining in tumor cells of 10 patients with IIIb stage, was observed. These results suggest that PCNA expression combined with pathohistological findings could possess a prognostic value in determining the survival rates for patients with oral squamous cell carcinoma.
Type: Article
DOI: 10.2298/ABS190705053L
ISSN: 03544664
SCOPUS: 85083338164
Appears in Collections:Faculty of Medical Sciences, Kragujevac
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