Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/11046
Title: NEDD4 Family of E3 Ubiquitin Ligases in Breast Cancer: Spotlight on SMURFs, WWPs and NEDD4
Authors: Butt G.
Yaylim I.
Attar, Rukset
Aras A.
Romero M.
Qureshi M.
Purenovic, Jelena
Farooqi, Ammad
Journal: Advances in Experimental Medicine and Biology
Issue Date: 1-Jan-2019
Abstract: © 2019, Springer Nature Switzerland AG. Massively parallel sequencing, genomic and proteomic technologies have provided near complete resolution of signaling landscape of breast cancer (BCa). NEDD4 family of E3-ubiquitin ligases comprises a large family of proteins particularly, SMURFs (SMURF1, SMURF2), WWPs and NEDD4 which are ideal candidates for targeted therapy. However, it is becoming progressively more understandable that SMURFs and NEDD4 have “split-personalities”. These molecules behave dualistically in breast cancer and future studies must converge on detailed identification of context specific role of these proteins in BCa. Finally, we provide scattered clues of regulation of SMURF2 by oncogenic miRNAs, specifically considering longstanding questions related to regulation of SMURF1 and WWPs by miRNAs in BCa. SMURFS, WWPs and NEDD4 are versatile regulators and represent a fast-growing field in cancer research and better understanding of the underlying mechanisms will be helpful in transition of our knowledge from a segmented view to a more conceptual continuum.
URI: https://scidar.kg.ac.rs/handle/123456789/11046
Type: Chapter
DOI: 10.1007/978-3-030-20301-6_19
ISSN: 00652598
SCOPUS: 85071776536
Appears in Collections:Faculty of Technical Sciences, Čačak
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