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Title: Naphthoquinone rich Onosma visianii Clem (Boraginaceae) root extracts induce apoptosis and cell cycle arrest in HCT-116 and MDA-MB-231 cancer cell lines
Authors: Vukić, Milena
Vukovic, Nenad
Obradović, Ana
Popovic, Suzana
Zaric, Milan
Djurdjevic, Predrag
Marković, Snežana
Baskic, Dejan
Issue Date: 2018
Abstract: © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group. In the present study, five root extracts of Onosma visianii Clem were investigated for their in vitro cytotoxic activity. On the basis of HPLC-PDA analysis, these extracts have proved to be a rich source of naphthoquinones as natural colourants for food and cosmetic industry. All investigated root extracts contain acetylshikonin, isobutyrylshikonin and α-methylbutyrylshikonin as major compounds. As the most abundant source of active compounds for antitumour therapy, acetone, chloroform and ethyl acetate extracts showed strong cytotoxic activity towards HCT-116 and MDA-MB-231 cancer cell lines. Also, these extracts induced apoptosis and cell cycle arrest in HCT-116 and MDA-MB-231 cancer cell lines.
Type: article
DOI: 10.1080/14786419.2017.1374271
ISSN: 1478-6419
SCOPUS: 2-s2.0-85029411156
Appears in Collections:Faculty of Medical Sciences, Kragujevac
Faculty of Science, Kragujevac

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