Please use this identifier to cite or link to this item:
Title: Kinetics and mechanism of interactions of some monofunctional Au(III) complexes with sulphur nucleophiles
Authors: Radisavljević, Snežana
Kesić, Ana
Jovanović, Snežana
Petrović, Biljana
Issue Date: 2018
Abstract: © 2018, Springer International Publishing AG, part of Springer Nature. Kinetics of the substitution reactions between monofunctional Au(III) complexes, [Au(dien)Cl]2+, [Au(bpma)Cl]2+ and [Au(terpy)Cl]2+ (dien = 3-azapentane-1,5-diamine, bpma = di-(2-picolyl) amine, terpy = 2,2′;6′,2″-terpyridine), and biologically relevant sulphur ligands, namely glutathione (GSH), l-methionine (l-Met) and l-cysteine (l-Cys), were studied in 0.1 M HCl (pH = 1.0). The reactions were followed under pseudo-first-order conditions as a function of ligand concentration and temperature using stopped-flow spectrophotometry. The [Au(terpy)Cl]2+ complex proved to be more reactive than the [Au(bpma)Cl]2+ and [Au(dien)Cl]2+ complexes. The reactivities of the nucleophiles follow the same order for all three complexes, viz. l-Met > GSH > l-Cys. Values of the activation parameters of the reactions support an associative substitution mechanism. In order to confirm that these monofunctional Au(III) complexes undergo a single substitution process in strongly acidic medium, the reaction between [Au(terpy)Cl]2+ and l-Met was studied by HPLC. At pH = 1.0, only one reaction product was detected.
Type: article
DOI: 10.1007/s11243-018-0221-9
ISSN: 0340-4285
SCOPUS: 2-s2.0-85045271514
Appears in Collections:Faculty of Science, Kragujevac

Page views(s)




Files in This Item:
File Description SizeFormat 
  Restricted Access
29.86 kBAdobe PDFThumbnail

Items in SCIDAR are protected by copyright, with all rights reserved, unless otherwise indicated.