Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/11213
Title: Estradiol decreases blood pressure in association with redox regulation in preeclampsia
Authors: Babic, Goran
Marković, Snežana
Varjacic, Mirjana
Djordjevic, Natasa
Nikolic Turnic T.
Stojic, Isidora
Jakovljevic V.
Issue Date: 2018
Abstract: © 2017 Taylor & Francis. In this study, we tested a hypothesis that a short-term estradiol therapy may reduce blood pressure in preeclampsia by modulating plasma oxidative stress. The intramuscular injections of 10 mg 17-beta-estradiol were prescribed to preeclamptic pregnant women during the 3-day therapy before a labor induction. The analyses of mean arterial pressure (MAP), serum estradiol concentrations, plasma superoxide anion (O2.), hydrogen peroxide (H2O2), nitrites (NO2−), and peroxynitrite (ONOO−) were conducted before and during the therapy. We found that the plasma concentrations of oxidative stress markers, such as O2– and H2O2, are higher in preeclampsia and positively correlated with the MAP value. Moreover, it was shown that the plasma concentration of NO2– as an indicator of NO levels is higher in preeclampsia. A short-term intramuscular application of estradiol decreases the MAP value and the plasma concentration of O.–, H2O2, NO2−, and ONOO– in preeclampsia. A positive correlation between the decrease of MAP values and the decrease of plasma concentrations of O2–, H2O2, and ONOO– was found in preeclampsia during a short-term estradiol therapy. We conclude that the short-term estradiol therapy decreases the MAP value in preeclampsia by modulating the plasma oxidative stress. We speculate that the estradiol metabolism in preeclampsia is an important mechanism that contributes to vascular dysfunction.
URI: https://scidar.kg.ac.rs/handle/123456789/11213
Type: article
DOI: 10.1080/10641963.2017.1368538
ISSN: 1064-1963
SCOPUS: 2-s2.0-85029599960
Appears in Collections:Faculty of Medical Sciences, Kragujevac
Faculty of Science, Kragujevac

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