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Назив: Pyrazoline derivatives of acryloyl substituted ferrocenyl ketones: Synthesis, antimicrobial activity and structural properties
Аутори: Burmudz̃ija A.
Muškinja, Jovana
Ratković, Zoran
Kosanic, Marijana
Ranković B.
Novakovic, Sladjana B.
Bogdanovic, Goran A.
Датум издавања: 2018
Сажетак: © 2017 Elsevier B.V. A series of ferrocenyl ketones were synthesized in reaction with ferrocene and corresponding substituted acryloyl chlorides, following previously described procedure. Synthesized products have conjugated enone system, which is suitable for further transformations. In a reaction with hydrazine in acidic medium (acetic acid) new pyrazoline derivatives were obtained. Their antimicrobial properties have been tested. Synthesized pyrazoline derivatives demonstrated expressed in vitro antimicrobial activity towards 12 strains of microorganisms inhibiting all tested bacteria and fungi. The most potent compound in all cases was sorbyl derivative; for bacteria activity was very close to streptomycin, and for fungi in one case the same as ketoconazole. It is established that this compound can be a new, potential antimicrobial agent with minimum inhibitory concentrations from 0.039 to 0.312 mg/mL. One of the starting compounds and two products were crystal substances, suitable for the single crystal X-ray diffraction analysis, which confirmed undoubtedly their structures.
URI: https://scidar.kg.ac.rs/handle/123456789/11250
Тип: article
DOI: 10.1016/j.ica.2017.11.061
ISSN: 0020-1693
SCOPUS: 2-s2.0-85037338796
Налази се у колекцијама:Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac

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