Please use this identifier to cite or link to this item:
Title: Composition and biological activities of different extracts of Salvia jurisicii, a rare and endemic Macedonian species
Authors: Alimpić Aradski A.
Knežević, Aleksandar
Ŝavikin K.
Ćurčić Milutinović, Milena
Velickovic D.
Stevic̈ T.
Matevski V.
Stajić M.
Marković, Snežana
Marin, Petar
Duletic-Lausevic, Sonja
Issue Date: 2017
Abstract: © 2016 Società Botanica Italiana. This is the first report on the phenolic composition and biological activities of endemic species Salvia jurisicii Košanin (Lamiaceae) originating from Macedonia. Aerial parts of S. jurisicii were extracted with dichloromethane, ethyl acetate, methanol, ethanol and water. All extracts were tested spectrophotometrically for total phenolic and flavonoid contents, while their phenolic composition was analyzed using HPLC-DAD. The antioxidant activity of extracts was studied using 2,2-dyphenyl-1-picrylhydrazyl, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), ferric reducing ability of plasma and ß-carotene bleaching assays. Being the most frequently used solvents for extraction of bioactive ingredients from medicinal plants, water and ethanol extracts were chosen for further testing of antimicrobial, cytotoxic and antineurodegenerative activities. More polar solvent extracts showed higher total phenolic content and lower flavonoid content. Ethanol and methanol extracts, followed by water extract exhibited the strongest antioxidant activity. Extracts showed antimicrobial activity against certain bacteria and micromycetes. The cytotoxicity assay showed slight toxicity to HCT-116 cell line. In the antineurodegenerative assays, the extracts performed lower inhibition of acetylcholinesterase and tyrosinase than standards. According to the results of this study, it can be inferred that more polar extracts of S. jurisicii were quantitatively richer in total phenolics, showing stronger antioxidant activity. Ethanol extract showed stronger biological activities comparing to water extract.
Type: article
DOI: 10.1080/11263504.2016.1219414
ISSN: 1126-3504
SCOPUS: 2-s2.0-84984706593
Appears in Collections:Faculty of Science, Kragujevac

Page views(s)




Files in This Item:
File Description SizeFormat 
  Restricted Access
29.86 kBAdobe PDFThumbnail

Items in SCIDAR are protected by copyright, with all rights reserved, unless otherwise indicated.