Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/11421
Title: Antioxidative and haematoprotective activity of coenzyme Q10 and Vitamin E against cadmium-induced oxidative stress in Wistar rats
Authors: Paunović, Milica
Matić, Miloš
Ognjanovic, Branka
Saicic Z.
Journal: Toxicology and Industrial Health
Issue Date: 1-Oct-2017
Abstract: © The Author(s) 2017. Cadmium (Cd) is a major environmental pollutant, which exerts adverse effects mainly by inducing oxidative stress. Coenzyme Q10 (CoQ10) and vitamin E (VE), naturally occurring antioxidants, improve health condition by inactivating free radicals and enhancing antioxidative defence. The aim of our study was to investigate the protective role of CoQ10 and/or VE pretreatment against Cd-induced haematotoxicity. Wistar albino rats were intramuscularly injected with CoQ10 (20 mg/kg b.w.) and/or VE (20 IU/kg b.w.) or with saline (control group). After 24 h, Cd was injected intraperitoneally (0.4 mg/kg b.w.) and 1 day after, animals were sacrificed. Acute Cd intoxication caused significant changes in haematological and biochemical parameters and altered the glutathione cycle, leading to the formation of lipid peroxidation, while the concentrations and activities of antioxidants (vitamins C and E, superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase) were decreased. CoQ10 and/or VE significantly maintained these values to near-normal levels, afforded additional protection by reducing lipid peroxidation and improved the levels of antioxidants in the blood. Plasma CoQ10 and VE levels negatively correlated with oxidative damage parameters while positively correlated with antioxidative defence parameters. Regarding their effects, CoQ10 and VE were in synergistic interaction. The present study suggested that CoQ10 and VE combination may be beneficial in protecting from Cd-induced haematotoxicity and may be used as a preventive against acute Cd intoxication of exposed people.
URI: https://scidar.kg.ac.rs/handle/123456789/11421
Type: Article
DOI: 10.1177/0748233717725480
ISSN: 07482337
SCOPUS: 85031754289
Appears in Collections:Faculty of Science, Kragujevac
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