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Title: Anxiety-like behavioural effects of extremely low-frequency electromagnetic field in rats
Authors: Djordjevic, Natasa
Paunović, Milica
Peulic A.
Issue Date: 2017
Abstract: © 2017, Springer-Verlag GmbH Germany. In recent years, extremely low-frequency electromagnetic field (ELF-EMF) has received considerable attention for its potential biological effects. Numerous studies have shown the role of ELF-EMF in behaviour modulation. The aim of this study was to investigate the effect of short-term ELF-EMF (50 Hz) in the development of anxiety-like behaviour in rats through change hypothalamic oxidative stress and NO. Ten adult male rats (Wistar albino) were divided in two groups: control group—without exposure to ELF-EMF and experimental group—exposed to ELF-EMF during 7 days. After the exposure, time open field test and elevated plus maze were used to evaluate the anxiety-like behaviour of rats. Upon completion of the behavioural tests, concentrations of superoxide anion (O2·−), nitrite (NO2−, as an indicator of NO) and peroxynitrite (ONOO−) were determined in the hypothalamus of the animals. Obtained results show that ELF-EMF both induces anxiety-like behaviour and increases concentrations of O2·− and NO, whereas it did not effect on ONOO− concentration in hypothalamus of rats. In conclusion, the development of anxiety-like behaviour is mediated by oxidative stress and increased NO concentration in hypothalamus of rats exposed to ELF-EMF during 7 days.
Type: article
DOI: 10.1007/s11356-017-9710-1
ISSN: 0944-1344
SCOPUS: 2-s2.0-85026452058
Appears in Collections:Faculty of Science, Kragujevac

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