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Title: Mesenchymal stem cell-derived factors: Immuno-modulatory effects and therapeutic potential
Authors: Volarevic, Vladislav
Gazdic, Marina
Simovic Markovic, Bojana
Jovicic, Nemanja
Djonov, Valentin
Arsenijevic, Nebojsa
Journal: BioFactors
Issue Date: 1-Sep-2017
Abstract: © 2017 International Union of Biochemistry and Molecular Biology Stem cell-based therapy is considered to be a new hope in transplantation medicine. Among stem cells, mesenchymal stem cells (MSCs) are, due to their differentiation and immuno-modulatory characteristics, the most commonly used as therapeutic agents in the treatment of immune-mediated diseases. MSCs migrate to the site of inflammation and modulate immune response. The capacity of MSC to alter phenotype and function of immune cells are largely due to the production of soluble factors which expression varies depending on the pathologic condition to which MSCs are exposed. Under inflammatory conditions, MSCs-derived factors suppress both innate and adaptive immunity by attenuating maturation and capacity for antigen presentation of dendritic cells, by inducing polarization of macrophages towards alternative phenotype, by inhibiting activation and proliferation of T and B lymphocytes and by reducing cytotoxicity of NK and NKT cells. In this review, we emphasized current findings regarding immuno-modulatory effects of MSC-derived factors and emphasize their potential in the therapy of immune-mediated diseases. © 2017 BioFactors, 43(5):633–644, 2017.
Type: Review
DOI: 10.1002/biof.1374
ISSN: 09516433
SCOPUS: 85025125532
Appears in Collections:Faculty of Medical Sciences, Kragujevac
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