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Title: The acute effects of different spironolactone doses on cardiac function in streptozotocin-induced diabetic rats
Authors: Vranic, Aleksandra
Simovic, Stefan
Ristic P.
Nikolic Turnic T.
Stojic, Isidora
Srejovic I.
Zivkovic V.
Jakovljevic V.
Djuric D.
Issue Date: 2017
Abstract: © 2017, Canadian Science Publishing. All rights reserved. Currently, cardiovascular diseases are the leading cause of global mortality, while diabetes mellitus remains an important cause of cardiovascular morbidity. A recent study showed that patients with diabetes mellitus treated with mineralocorticoid receptor antagonists have improved coronary microvascular function, leading to improved diastolic dysfunction. In this study, we evaluated the influence of acute administration of spironolactone on myocardial function in rats with streptozotocin-induced diabetes mellitus, with special emphasis on cardiodynamic parameters in diabetic rat hearts. The present study was carried out on 40 adult male Wistar albino rats (8 weeks old). Rats were randomly divided into 4 groups (10 animals per group): healthy rats treated with 0.1 μmol/L of spironolactone, diabetic rats treated with 0.1 μmol/L of spironolactone, healthy rats treated with 3 μmol/L of spironolactone, and diabetic rats treated with 3 μmol/L of spironolactone. Different, dose-dependent, acute responses of spironolactone treatment on isolated, working diabetic and healthy rat heart were observed in our study. In healthy rats, better systolic function was achieved with higher spironolactone dose, while in diabetic rats, similar effects of low and high spironolactone dose were observed.
Type: article
DOI: 10.1139/cjpp-2017-0055
ISSN: 0008-4212
SCOPUS: 2-s2.0-85032455289
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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