Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/11652
Title: Angiotensin Receptor Blocker Losartan Inhibits Spontaneous Motility of Isolated Human Ureter
Authors: Jankovic, Slobodan
Stojadinovic, Dobrivoje
Stojadinovic, Miroslav
Jankovic O.
Djuric, Janko
Stojic, Isidora
Kostic M.
Journal: European Journal of Drug Metabolism and Pharmacokinetics
Issue Date: 1-Dec-2016
Abstract: © 2015, Springer International Publishing Switzerland. Background and Objectives: Ureteral motility is essential for elimination of intraluminal stones, and it may be adversely affected by cardiovascular drugs that a patient is taking chronically. The aim of our study was to test whether ACE inhibitors and an angiotensin receptor blocker may influence spontaneous contractions of isolated human ureter. Methods: Both phasic and tonic contractions of the isolated ureteral segments taken from 10 patients were measured as changes of the longitudinal tension or pressure recordings. Captopril, enalapril and losartan were separately added to the organ baths cumulatively. Results: While enalapril (2.7 × 10−7–3.9 × 10−4 M) and captopril (6.1 × 10−7–2.7 × 10−3 M) did not affect either spontaneous activity or tone of isolated ureteral segments, losartan (2.9 × 10−7–4.2 × 10−4 M) caused concentration-dependent inhibition of spontaneous contractions of the segments (50 % effective concentration (EC50) = 13.46 ± 1.80 × 10−6 M; F = 10.72, r = 0.79, p < 0.001). Conclusions: Due to differences in molecular mechanism of action, angiotensin receptor blocker losartan does and ACE inhibitors captopril and enalapril do not inhibit spontaneous contractions of isolated human ureter.
URI: https://scidar.kg.ac.rs/handle/123456789/11652
Type: Article
DOI: 10.1007/s13318-015-0298-x
ISSN: 03787966
SCOPUS: 84940571094
Appears in Collections:Faculty of Medical Sciences, Kragujevac
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