Please use this identifier to cite or link to this item:
Title: New gold carbene complexes as candidate anticancer agents
Authors: Pratesi, Alessandro
Đurović, Mirjana
Pillozzi S.
Petroni, Giulia
Bugarčić, Živadin
messori, luigi
Issue Date: 2016
Abstract: © 2016, Springer Science+Business Media New York. Three structurally related gold(I) carbene complexes with bulky hydrophobic ligands i.e. 1–3 were investigated in solution for further consideration as candidate anticancer agents. Cytotoxic assays were subsequently conducted on bone marrow-derived preosteoclast cell line of human origin (FLG 29.1) and human colon cancer cells (HCT-116). A far greater cytotoxic activity was measured for compound 1 against HCT-116 cells compared to 2 and 3; conversely, all compounds were highly and similarly active against FLG 29.1 cells. Results obtained for the reaction of complexes 1 and 2 with RNase A documented the occurrence of a weak interaction with this model protein and the formation of a tiny amount of the corresponding adduct. Moreover, a certain reactivity of the complex 2 was also detected toward GSH. The general implications of the obtained results are discussed.
Type: article
DOI: 10.1007/s10534-016-9962-0
ISSN: 0966-0844
SCOPUS: 2-s2.0-84983000184
Appears in Collections:Faculty of Science, Kragujevac

Page views(s)




Files in This Item:
File Description SizeFormat 
  Restricted Access
29.86 kBAdobe PDFThumbnail

Items in SCIDAR are protected by copyright, with all rights reserved, unless otherwise indicated.