Please use this identifier to cite or link to this item:
Title: Cytotoxicity of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-ethyl derivative of thiosalicylic acid
Authors: Nikolic, Milos
Mijajlovic M.
Jevtić, Verica
Ratković, Zoran
Novakovic, Sladjana B.
Bogdanovic, Goran A.
Milovanovic, Jelena
Arsenijevic A.
Stojanovic B.
Trifunović, Srećko
Radic G.
Issue Date: 2016
Abstract: © 2016 Published by Elsevier B.V. The spectroscopically predicted structure of the obtained copper(II)-complex with S-ethyl derivative of thiosalicylic acid was confirmed by X-ray structural study and compared to previously reported crystal structure of the Cu complex with S-methyl derivative. Single crystals suitable for X-ray measurements were obtained by slow crystallization from a water solution. Cytotoxic effects of S-alkyl (R = benzyl (L1), methyl (L2), ethyl (L3), propyl (L4) and butyl (L5)) derivatives of thiosalicylic acid and the corresponding binuclear copper(II)-complexes on murine colon carcinoma cell lines, CT26 and CT26.CL25 and human colon carcinoma cell line HCT-116 were reported here. The analysis of cancer cell viability showed that all the tested complexes had low cytotoxic effect on murine colon carcinoma cell lines, but several times higher cytotoxicity on normal human colon carcinoma cells.
Type: article
DOI: 10.1016/j.molstruc.2016.03.058
ISSN: 0022-2860
SCOPUS: 2-s2.0-84961661678
Appears in Collections:Faculty of Medical Sciences, Kragujevac
Faculty of Science, Kragujevac

Page views(s)




Files in This Item:
File Description SizeFormat 
  Restricted Access
29.86 kBAdobe PDFThumbnail

Items in SCIDAR are protected by copyright, with all rights reserved, unless otherwise indicated.