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Title: Population Pharmacokinetics of Bisoprolol in Hemodialysis Patients with Hypertension
Authors: Nikolic V.
Jankovic, Slobodan
Dimitrijevic, Zorica
Sokolovic M.
Andric B.
Petrovic, Dejan
Jevtovic Stoimenov, Tatjana
Živanović, Slavoljub
Milovanovic, Jasmina
Issue Date: 2016
Abstract: © 2016 S. Karger AG, Basel. The aim of our study was to estimate clearance of bisoprolol and reveal the factors that could influence its pharmacokinetic (PK) variability in hypertensive patients on hemodialysis, using the population PK analysis. Parameters associated with plasma concentration of bisoprolol at steady state were analyzed in 63 patients (mean age 62.12 years, mean total weight 69.63 kg) who were hypertensive and on hemodialysis due to severe renal failure using non-linear mixed-effect modeling with ADVAN1 subroutine. The final regression model for the clearance of the drug included only creatinine clearance (CLcr) out of 12 tested covariates. The equation that describes CL of bisoprolol is the following: CL (l/h) = 0.12 + 6.33 ∗ CLcr. These findings suggest that the routine measuring of serum creatinine level may be used to facilitate administration of bisoprolol in patients on hemodialysis.
Type: article
DOI: 10.1159/000443179
ISSN: 0031-7012
SCOPUS: 2-s2.0-84953774620
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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