Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/11868
Title: Hyperlactatemia and the Outcome of Type 2 Diabetic Patients Suffering Acute Myocardial Infarction
Authors: Aleksandar J.
Peric, Vladan
Markovic - Jovanovic, Snezana
Stolic, Radojica
Mitic J.
Smilić T.
Issue Date: 2016
Abstract: © 2016 Jovanovic Aleksandar et al. Background. Increased lactate production is frequent in unregulated/complicated diabetes mellitus. Methods. Three groups, each consisting of 40 patients (type 2 diabetics with myocardial infarction, DM+AMI, nondiabetics suffering myocardial infarction, MI, and diabetics with no apparent cardiovascular pathology, DM group), were tested for pH, serum bicarbonate and electrolytes, blood lactate, and CK-MB. Results. Blood lactate levels were markedly higher in AMI+DM compared to MI group (4.54±1.44 versus 3.19±1.005 mmol/L, p<0.05); they correlated with the incidence of heart failure (ρ=0.66), cardiac rhythm disorders (ρ=0.54), oxygen saturation (ρ=0.72), CK-MB levels (ρ=0.62), and poor short-term outcome. Lactic acidosis in DM+AMI group was not always related to lethal outcome. Discussion. The lactate cutoff value associated with grave prognosis depends on the specific disease. While some authors proposed cutoff values ranging from 0.76 to 4 mmol/L, others argued that only occurrence of lactic acidosis may be truly predictive of lethal outcome. Conclusion. Both defective glucose metabolism and low tissue oxygenation may contribute to the lactate production in diabetic patients with acute myocardial infarction; high lactate levels indicate increased risk for poor outcome in this population comparing to nondiabetic patients. The rise in blood lactate concentration in diabetics with AMI was associated with increased incidence of heart failure, severe arrhythmias, cardiogenic shock, and high mortality rate.
URI: https://scidar.kg.ac.rs/handle/123456789/11868
Type: article
DOI: 10.1155/2016/6901345
ISSN: 2314-6745
SCOPUS: 2-s2.0-84999700191
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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