Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/11902
Title: Expression of interleukin-33 and its receptor ST2 in periapical granulomas and radicular cysts
Authors: Velickovic M.
Pejnović, Nada
Petrovic R.
Mitrovic O.
Jeftic, Ilija
Kanjevac, Tatjana
Lukic, Aleksandra
Journal: Journal of Oral Pathology and Medicine
Issue Date: 1-Jan-2016
Abstract: © 2015 John Wiley & Sons A/S. Background: Interleukin-33 (IL-33) is a recently identified cytokine belonging to the IL-1 family and ligand for the IL-1 receptor-related protein ST2. IL-33/ST2 signaling plays a critical role in allergy, autoimmunity, and chronic inflammatory disorders, but its role in the pathogenesis of periapical lesions is unknown. We aimed to investigate the expression patterns of IL-33 and ST2 in human periapical lesions. Methods: Periapical lesions (n = 36) and healthy periapical tissues (n = 10) were evaluated by immunohistochemistry using antibodies specific for human IL-33 and ST2. Lesion samples were further analyzed by double immunofluorescence to assess IL-33/ST2 co-expression. Results: The numbers of IL-33- and ST2-positive fibroblasts were significantly higher in periapical lesions compared to healthy periapical tissues (both P < 0.05), while the numbers of IL-33- and ST2-positive endothelial cells were similar (both P > 0.05). There were no significant differences in the numbers of IL-33- and ST2-positive fibroblasts and endothelial cells between periapical granulomas and radicular cysts (all P > 0.05). Similarly, numbers of ST2-positive mononuclear cells did not differ between periapical granulomas and radicular cysts (P > 0.05). The majority of epithelial cells in radicular cysts were IL-33 positive, while the small proportion of epithelial cells was ST2 positive. Double immunofluorescence analysis revealed IL-33/ST2 co-expression in fibroblasts and endothelial cells. Conclusions: IL-33 and ST2 are expressed in periapical granulomas and radicular cysts. Increased numbers of IL-33- and ST2-positive fibroblasts in periapical lesions when compared to healthy periapical tissues suggest that IL-33/ST2 signaling may be involved in periapical inflammation and tissue fibrosis.
URI: https://scidar.kg.ac.rs/handle/123456789/11902
Type: article
DOI: 10.1111/jop.12312
ISSN: 09042512
SCOPUS: 84955747679
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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