Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/12000
Title: Cytokine production in patients with papillary thyroid cancer and associated autoimmune Hashimoto thyroiditis
Authors: Zivancevic-Simonovic, Snezana
Vrndic O.
Majstorovic I.
Popovic, Suzana
Markovic, Slavica
Milošević-Đorđević, Olivera
Jovanovic, Zorica
Mijatovic Teodorovic, Ljiljana
Mihajlovic D.
Colic, Miodrag
Journal: Cancer Immunology, Immunotherapy
Issue Date: 28-Aug-2015
Abstract: © Springer-Verlag Berlin Heidelberg 2015. Hashimoto thyroiditis (HT) is the most frequent thyroid autoimmune disease, while papillary thyroid cancer (PTC) is one of the most common endocrine malignancies. A few patients with HT also develop PTC. The aim of this study was to analyze cytokine profiles in patients with PTC accompanied with autoimmune HT in comparison with those in patients with PTC alone or HT alone and healthy subjects. Cytokine levels were determined in supernatants obtained from phytohemagglutinin (PHA)-stimulated whole blood cultures in vitro. The concentrations of selected cytokines: Th1—interferon gamma (IFN-γ); Th2—interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin 6 (IL-6), interleukin 10 (IL-10) and interleukin 13 (IL-13); Th9—interleukin 9 (IL-9); and Th17—interleukin 17 (IL-17A) were measured using multiplex cytokine detection systems for human Th1/Th2/Th9/Th17/Th22. We found that PTC patients with HT produced significantly higher concentrations of IL-4, IL-6, IL-9, IL-13 and IFN-γ than PTC patients without HT. In conclusion, autoimmune HT affects the cytokine profile of patients with PTC by stimulating secretion of Th1/Th2/Th9 types of cytokines. Th1/Th2 cytokine ratios in PTC patients with associated autoimmune HT indicate a marked shift toward Th2 immunity.
URI: https://scidar.kg.ac.rs/handle/123456789/12000
Type: journal article
DOI: 10.1007/s00262-015-1705-5
ISSN: 03407004
SCOPUS: 84937974076
Appears in Collections:Faculty of Medical Sciences, Kragujevac
Faculty of Science, Kragujevac

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