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Title: Synthesis and antimicrobial/cytotoxic assessment of ferrocenyl oxazinanes, oxazinan-2-ones, and tetrahydropyrimidin-2-ones
Authors: Pejović, Anka
Danneels B.
Desmet T.
Cham B.
Nguyen V.
Radulovic, Niko
Vukicevic R.
D'hooghe, Matthias
Journal: Synlett
Issue Date: 2-Jun-2015
Abstract: © Georg Thieme Verlag. Abstract 3-Arylamino-1-ferrocenylpropan-1-ones, prepared through aza-Michael addition of aromatic amines to 1-ferrocenylpropenone, were transformed into the corresponding 1,3-amino alcohols upon NaBH4-mediated carbonyl reduction. The latter amino alcohols were deployed as eligible substrates for the synthesis of a variety of ferrocene-containing heterocycles including 1,3-oxazinanes, 1,3-oxazinan-2-ones, and tetrahydropyrimidin-2-ones, which were subsequently evaluated for their antimicrobial and cytotoxic activities.
Type: Article
DOI: 10.1055/s-0034-1380348
ISSN: 09365214
SCOPUS: 84929836855
Appears in Collections:Faculty of Science, Kragujevac
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