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Title: Cytotoxicity of palladium(II) complexes with some alkyl derivates of thiosalicylic acid. Crystal structure of the bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)<inf>2</inf>]
Authors: Mijajlovic M.
Nikolic, Milos
Jevtić, Verica
Ratković, Zoran
Simovic Markovic, Bojana
Volarevic, Vladislav
Arsenijevic, Nebojsa
Novakovic, Sladjana B.
Bogdanovic, Goran A.
Trifunović, Srećko
Radic G.
Issue Date: 2015
Abstract: © 2015 Elsevier Ltd. All rights reserved. The spectroscopically predicted structure of the obtained bis(S-butyl-thiosalicylate)palladium(II) complex, [Pd(S-bu-thiosal)2], was confirmed by an X-ray structural study. The asymmetric unit of [Pd(S-bu-thiosal)2] consists of neutral complex molecules, where the Pd(II) ion is placed in a cis-square-planar coordination environment formed by O and S atoms of two deprotonated S-butyl-thiosalicylic acid ligands. The cytotoxic effects of the S-alkyl (R = benzyl (L1), methyl (L2), ethyl (L3), propyl (L4) and butyl (L5)) derivatives of thiosalicylic acid and the corresponding palladium(II) complexes are reported here. The analysis of cancer cell viability showed that all the tested complexes are cytotoxic to human colon carcinoma cells (HCT-116 and CaCo-2) and human lung carcinoma epithelial cells (A549). The antitumor activities of the above mentioned Pd(II) complexes are higher in comparison to the corresponding ligands.
Type: article
DOI: 10.1016/j.poly.2015.01.041
ISSN: 0277-5387
SCOPUS: 2-s2.0-84923534983
Appears in Collections:Faculty of Medical Sciences, Kragujevac
Faculty of Science, Kragujevac

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