Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/12139
Title: Analysis of the cost-effectiveness of dronedarone versus amiodarone, propafenone, and sotalol in patients with atrial fibrillation: Results for Serbia
Authors: Tesic D.
Kostic M.
Paunovic D.
Jankovic, Slobodan
Journal: Kardiologia Polska
Issue Date: 1-Jan-2015
Abstract: Copyright © Polskie Towarzystwo Kardiologiczne. Background: Recent studies have shown that dronedarone is associated with signifcantly fewer adverse effects and treatment discontinuations, and a trend toward reduced all-cause mortality, compared with amiodarone. Introduction of dronedarone in clinical practice is limited by its higher cost than amiodarone, propafenone, and sotalol. Aim: To estimate cost-effectiveness of dronedarone versus amiodarone, propafenone, and sotalol in patients with atrial fbrillation (AF). Methods: We constructed a Markov model, which was then simulated by Monte Carlo simulation using 1,000 virtual patients. Costs and outcomes were estimated from the societal perspective and discounted at 3% annually. A lifetime horizon and three-month cycle length were used. The main outcome measurement was the number of years spent without stroke. Values of transition probabilities and therapy outcomes were estimated from available literature. The prices of health services and drugs were obtained from the Republic Institute for Health Insurance Tariff Book and Drug List A and from the drug developer. Results: Cost-effectiveness shows that the dronedarone treatment option has the most advantageous relationship, where, for one year without a stroke, the total cost is €1,779.23. In the case of the amiodarone therapy option, for one year without a stroke €3,845.10 is needed, for propafenone €4,674.20, while for sotalol the sum is €14,973.89. Estimated annual costs for patients with frst-detected AF in Serbia were €610. Conclusions: The results of our model indicate that dronedarone is a cost-effective therapy compared with amiodarone, propafenone, and sotalol in patients with A F, if the outcome measurement is the number of years spent without stroke.
URI: https://scidar.kg.ac.rs/handle/123456789/12139
Type: Article
DOI: 10.5603/KP.a2014.0228
ISSN: 00229032
SCOPUS: 84928139291
Appears in Collections:Faculty of Medical Sciences, Kragujevac
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