Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/12299
Title: The role of biochemical markers as early indicators of cardiac damage and prognostic parameters of perinatal asphyxia
Authors: Simovic, Aleksandra
Kosutic, Jovan
Prijić, Sergej
Knezevic, Jasmina
Vujic, Ana
Stojanovic, Nadežda
Issue Date: 2014
Abstract: Background/Aim. In recent years, the focus of interest of the scientific community is the application of heart markers as early indicators and prognostic parameters of perinatal asphyxia (PA). The aim of this study was to evaluate the significance of clinical application of heart markers in term newborns with perinatal asphyxia. Methods. During a 3- year period we analyzed 91 full-term newborns (55 with and 36 without perinatal asphyxia). In all the subjects within the first 24-48 h after birth, we simultaneously determined serum concentrations of cardiac troponin I, brain natriuretic peptide, MB fraction of creatine kinase (CK-MB) and Creactive protein. Results. In the group of full-term neonates with PA significantly higher levels of cardiac troponinI (p = 0.000), CK-MB fraction (p = 0.000), brain natriuretic peptide (p = 0.003) and C-reactive protein (p = 0.017) were found, compared to the group of healthy full-term newborns. In merged group (n = 91) cardiac troponin I level correlated with the fifth minute Apgar score (r = - 0.637, p = 0.000) and the serum lactate concentration in the first 12h after birth (r = 0.529, p = 0.000). Early increase in cardiac troponin I > 0.135 μg/L predicted the risk of death with the sensitivity of 84.6% and specificity of 85.9%, while the increase in CK-MB fraction, brain natriuretic peptide and C-reactive protein did not have a predictive value with respect to a mortality outcome. Conclusion. Among the tested cardiac markers, cardiac troponin I is the most sensitive and the only reliable early predictor of mortality in fullterm neonates with perinatal asphyxia.
URI: https://scidar.kg.ac.rs/handle/123456789/12299
Type: article
DOI: 10.2298/VSP1402149S
ISSN: 0042-8450
SCOPUS: 2-s2.0-84893838075
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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