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Title: HER2-positive breast cancer patients: Correlation between mammographic and pathological findings
Authors: Radenković N.
Konjević G.
Isakovic, Andjelka
Stevanović P.
Gopčević K.
Jurisic, Vladimir
Issue Date: 2014
Abstract: © The Author 2014. Human epidermal growth factor receptor 2 (HER2)-positive breast cancers represent a highly aggressive breast cancer subtype and are associated with a worse prognosis. This study was designed to investigate the mammography finding of HER2-positive breast cancer and to compare the results with the characteristics of HER2-negative breast cancer patients. From January 2010 to October 2011, mammography findings of 65 patients with pathologically confirmed HER2-positive breast cancers (n 5 22) or HER2-negative breast cancers (n 5 43) were retrospectively reviewed. The authors also reviewed pathological reports for information on the histological type and differentiation grade. Among the two types of breast cancer patients, estrogen receptornegative/PR-negative/HER2-positive breast cancer patients most commonly had associated calcifications (18 of 22) on mammography. On mammography, cases with a cluster of calcifications usually were presented as pleomorphic calcifications (12 of 20) and branching calcifications (4 of 20). Patients with HER2-positive breast cancers showed a histological grade II. HER2-positive breast cancer patients usually had ductal invasive carcinoma (17 of 22). Moreover, postmenopausal patients showed a significantly higher frequency of HER2-positive tumours. Our results suggest that the imaging findings might be useful in diagnosing HER2-positive breast cancer patients.
Type: article
DOI: 10.1093/rpd/ncu243
ISSN: 0144-8420
SCOPUS: 2-s2.0-84922418084
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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