Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/12412
Title: Copper-induced changes of lipid peroxidation and hemato-biochemical parameters in rat blood: Protective role of flavonoids
Authors: Mladenovic, Jelena
Paunović, Milica
Matić, Miloš
Knežević, Veroljub
Ognjanovic, Branka
Štajn A.
Saicic Z.
Journal: Archives of Biological Sciences
Issue Date: 1-Jan-2014
Abstract: The effects of subchronic exposure to copper (Cu) on lipid peroxidation, hemato-biochemical parameters, and the possible protective role of flavonoids Quercetin and (-)-Epicatechin were studied. Male Wistar albino rats were treated with Cu (560 mg/L, p.o. as CuCl2·2H2O for 5 weeks) and Quercetin and (-)-Epicatechin (40 mg/kg BW each, i.p., every third day during the last 3 weeks) alone or in combination. Cu increased the concentration of lipid peroxides, decreased the number of erythrocytes, hemoglobin and hematocrit values and increased the activities of aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase. Coadministration of Quercetin and (-)-Epicatechin with Cu lowered the process of lipid peroxidation and restored examined hemato-biochemical parameters to control values. Our results indicate that Cu induced oxidative damage in erythrocytes, which led to anemia, while Quercetin and (-)-Epicatechin showed a protective effect on the hemato-biochemical processes in the blood of rats.
URI: https://scidar.kg.ac.rs/handle/123456789/12412
Type: Article
DOI: 10.2298/ABS1403271M
ISSN: 03544664
SCOPUS: 84908159481
Appears in Collections:Faculty of Science, Kragujevac
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