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Title: Novel anthraquinone based chalcone analogues containing an imine fragment: Synthesis, cytotoxicity and anti-angiogenic activity
Authors: Kolundžija B.
Marković, Violeta
Stanojkovic, Tatjana
Joksović, Ljubinka
Matic, Ivana
Todorovic N.
Nikolic M.
Joksović, Milan
Journal: Bioorganic and Medicinal Chemistry Letters
Issue Date: 1-Jan-2014
Abstract: A new class of imine derivatives of hybrid chalcone analogues containing anthraquinone scaffold was synthesized and evaluated for their in vitro cytotoxic activity against HeLa, LS174, and A549 cancer cells. The compound 5n with furan ring linked to imino group showed potent activity against all target cells with IC50 values ranging from 1.76 to 6.11 μM. A mode of action study suggested that compounds induced changes typical for apoptosis in HeLa cells. The most active compounds inhibited tubulogenesis and 5h was found to exhibit a strong anti-angiogenic effect. © 2013 Elsevier Ltd. All rights reserved.
Type: Article
DOI: 10.1016/j.bmcl.2013.11.075
ISSN: 0960894X
SCOPUS: 84891488134
Appears in Collections:Faculty of Science, Kragujevac
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