Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/12450
Title: Synthesis, characterization, and antimicrobial evaluation of a small library of ferrocene-containing acetoacetates and phenyl analogs: The discovery of a potent anticandidal agent
Authors: Radulovic, Niko
Mladenović, Marko
Stojanović-Radić, Zorica
Bogdanovic, Goran A.
Stevanović, Dragana
Vukicevic R.
Journal: Molecular Diversity
Issue Date: 1-Jan-2014
Abstract: A library of 16 2-substituted methyl acetoacetates containing ferrocenyl or phenyl units was designed to disclose differences in the antimicrobial activity of ferrocene-containing compounds and their phenyl analogs. Two methyl acetoacetates, whose structures do not contain an aromatic nucleus, were also included in order to probe the inherent activity of the scaffold itself. The acetoacetates were synthesized (low-to-good yields) and fully characterized by spectral (MS, IR, UV-Vis, 1D and 2D NMR) and electrochemical (cyclic voltammetry) techniques. Single-crystal X-ray analysis has been performed for methyl 2-acetyl-2-(ferrocenylmethyl)-5-methylhex-4-enoate. All compounds have demonstrated in vitro antimicrobial activity against six bacterial (three Gram-positive and three Gram-negative) and two fungal strains with minimal inhibitory concentration values of 0.0050-20.6 μ mol mL-1. The most active compound was 2-acetyl-2-(ferrocenylmethyl)-4-methylpent-4-enoate whose activity was comparable to that of nystatin against the yeast Candida albicans. Agglomerative hierarchical clustering statistical analysis of the antimicrobial assay data demonstrated that ferrocene-containing compounds have statistically different and greater antimicrobial activity when compared to their phenyl analogs. © 2014 Springer International Publishing.
URI: https://scidar.kg.ac.rs/handle/123456789/12450
Type: article
DOI: 10.1007/s11030-014-9511-0
ISSN: 13811991
SCOPUS: 84903818508
Appears in Collections:Faculty of Science, Kragujevac

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