Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/12635
Title: Randomized controlled comparison of optimal medical therapy with percutaneous recanalization of chronic total occlusion (COMET-CTO)
Authors: Juricic S.
Tesic, Milorad
Galassi A.
Petrovic O.
Dobric M.
Orlic D.
Vukcevic V.
Stankovic, Goran
Aleksandrić B.
Tomasević M.
Nedeljkovic M.
Beleslin B.
Jelić D.
Ostojic M.
Stojković A.
Journal: International Heart Journal
Issue Date: 1-Jan-2021
Abstract: © 2021, International Heart Journal Association. All rights reserved. The aim of this randomized prospective study was to evaluate the quality of life (QoL) using the “Seattle Angina Questionnaire” (SAQ) in patients with chronic total occlusion (CTO) in coronary arteries treated with either percutaneous coronary intervention (PCI) or optimal medical therapy (OMT), or only with OMT. The potential benefits of recanalization of CTO by PCI have been controversial because of the scarcity of randomized controlled trials. A total of 100 patients with CTO were randomized (1:1) prospectively into the PCI CTO or the OMT group (50 patients in each group). There were no baseline differences in the SAQ scores between the groups, except for physical limitation scores (P = 0.03). During the mean follow-up (FUP) of 275 ± 88 days, patients in the PCI group reported less physical activity limitations (72.7 ± 21.3 versus 60.5 ± 27, P = 0.014), less frequent angina episodes (89.8 ± 17.6 versus 76.8 ± 27.1, P = 0.006), better QoL (79.9 ± 22.7 versus 62.5 ± 25.5, P = 0.001), greater treatment satisfaction (91.2 ± 13.6 versus 81.4 ± 18.4, P = 0.003), and borderline differences in angina stability (61.2 ± 26.5 versus 51.0 ± 23.7, P = 0.046) compared to patients in the OMT group. There were no significant differences in SAQ scores in the OMT group at baseline and during the FUP. There was a statistically significant increase in all five domains in the PCI group. Symptoms and QoL measured by the SAQ were significantly improved after CTO PCI compared to OMT alone.
URI: https://scidar.kg.ac.rs/handle/123456789/12635
Type: Article
DOI: 10.1536/ihj.20-427
ISSN: 13492365
SCOPUS: 85100018968
Appears in Collections:University Library, Kragujevac
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