Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/12649
Full metadata record
DC FieldValueLanguage
dc.contributor.authorJoksimović N.-
dc.contributor.authorJanković, Nenad-
dc.contributor.authorDavidovic G.-
dc.contributor.authorBugarčić Z.-
dc.date.accessioned2021-04-20T21:22:54Z-
dc.date.available2021-04-20T21:22:54Z-
dc.date.issued2020-12-01-
dc.identifier.issn00452068-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/12649-
dc.description.abstract© 2020 Elsevier Inc. Convenient structures such as 2,4-diketo esters have been widely used as an effective pattern in medicinal chemistry and pharmacology for drug discovery. 2,4-Diketonate is a common scaffold that can be found in many biologically active and naturally occurring compounds. Also, many 2,4-diketo ester derivatives have been prepared due to their suitable synthesis. These synthetic drugs and natural products have shown numerous interesting biological properties with clinical potential as a cure for the broad specter of diseases. This review aims to highlight the important evidence of 2,4-diketo esters as a privileged scaffold in medicinal chemistry and pharmacology. Herein, numerous aspects of 2,4-diketo esters will be summarized, including synthesis and isolation of their derivatives, development of novel synthetic methodologies, the evaluation of their biological properties as well as the mechanisms of action of the diketo ester derivates. This paperwork is expected to be a comprehensive, trustworthy, and critical review of the 2,4-diketo ester intermediate to the chemistry community.-
dc.relation.ispartofBioorganic Chemistry-
dc.title2,4-Diketo esters: Crucial intermediates for drug discovery-
dc.typereview-
dc.identifier.doi10.1016/j.bioorg.2020.104343-
dc.identifier.scopus85092749314-
Appears in Collections:Institute for Information Technologies, Kragujevac

Page views(s)

104

Downloads(s)

3

Files in This Item:
File Description SizeFormat 
PaperMissing.pdf
  Restricted Access
29.86 kBAdobe PDFThumbnail
View/Open


Items in SCIDAR are protected by copyright, with all rights reserved, unless otherwise indicated.