Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/12728
Title: Potential Antitumor Effect of Newly Synthesized Dinuclear1,5-Naphthyridine-Bridging Palladium(II) Complexes
Authors: Boskovic, Marina
Franich A.
Rajković, Snežana
Jovanovic M.
Jurisevic M.
Gajovic N.
Jovanovic M.
Arsenijevic, Nebojsa
Jovanovic I.
Zivkovic, Marija
Journal: ChemistrySelect
Issue Date: 14-Sep-2020
Abstract: © 2020 Wiley-VCH GmbH Five new dinuclear palladium(II) complexes with general formula, [{Pt(L)Cl}2(μ-1,5-nphe)](NO3)2 (L is ethylenediamine (en), (±)-1,2-propylenediamine (1,2-pn), trans-(±)-1,2-diaminocyclohexane (dach), 1,3-propylenediamine (1,3-pd), (±)-1,3-pentanediamine (1,3-pnd) and 1,5-nphe is bridging 1,5-naphthyridine ligand) were synthesised and spectroscopically characterized. In vitro cytotoxic activity of these complexes was evaluated against mouse mammary carcinoma (4T1), colon (CT26), lung cancer cells (LLC1) and melanoma (B16-F10) as well as human lung adenocarcinoma (A549), mammary carcinoma (MDA-MB-468), and colon cancer (HCT 116). The investigated complexes reduced viability of tumor cells in dose dependent manner. Dinuclear Pd(II) complexes act less cytotoxic toward tumor cells, compare to cisplatin, but also have greater selectivity toward mesenchymal stem cells. The potential mechanism of cell death of tumor cells treated with palladium(II) 1,5-naphthyridine dinuclear complexes is enhanced apoptosis, facilitated by down-regulation of anti-apoptotic Bcl-2 and up-regulation of pro-apoptotic Caspase-3.
URI: https://scidar.kg.ac.rs/handle/123456789/12728
Type: journal article
DOI: 10.1002/slct.202002350
SCOPUS: 85090992713
Appears in Collections:Faculty of Medical Sciences, Kragujevac
Faculty of Science, Kragujevac

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