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Title: Potential Antitumor Effect of Newly Synthesized Dinuclear1,5-Naphthyridine-Bridging Palladium(II) Complexes
Authors: Boskovic, Miladin
Franich Anđela
Rajković, Snežana
Jovanovic, Marina
Jurisevic, Milena
Gajovic, Nevena
Jovanovic, Marina
Arsenijevic, Nebojsa
Jovanovic, Ivan
Zivkovic, Marija
Issue Date: 2020
Abstract: © 2020 Wiley-VCH GmbH Five new dinuclear palladium(II) complexes with general formula, [{Pt(L)Cl}2(μ-1,5-nphe)](NO3)2 (L is ethylenediamine (en), (±)-1,2-propylenediamine (1,2-pn), trans-(±)-1,2-diaminocyclohexane (dach), 1,3-propylenediamine (1,3-pd), (±)-1,3-pentanediamine (1,3-pnd) and 1,5-nphe is bridging 1,5-naphthyridine ligand) were synthesised and spectroscopically characterized. In vitro cytotoxic activity of these complexes was evaluated against mouse mammary carcinoma (4T1), colon (CT26), lung cancer cells (LLC1) and melanoma (B16-F10) as well as human lung adenocarcinoma (A549), mammary carcinoma (MDA-MB-468), and colon cancer (HCT 116). The investigated complexes reduced viability of tumor cells in dose dependent manner. Dinuclear Pd(II) complexes act less cytotoxic toward tumor cells, compare to cisplatin, but also have greater selectivity toward mesenchymal stem cells. The potential mechanism of cell death of tumor cells treated with palladium(II) 1,5-naphthyridine dinuclear complexes is enhanced apoptosis, facilitated by down-regulation of anti-apoptotic Bcl-2 and up-regulation of pro-apoptotic Caspase-3.
Type: article
DOI: 10.1002/slct.202002350
SCOPUS: 2-s2.0-85090992713
Appears in Collections:Faculty of Medical Sciences, Kragujevac
Faculty of Science, Kragujevac

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