Please use this identifier to cite or link to this item:
Title: The effects of valsartan on cardiac function and pro-oxidative parameters in the streptozotocin-induced diabetic rat heart
Authors: Ravic, Marko
Jakovljevic, Vladimir
Ristic Petar
Srejovic, Ivan
Vranic, Aleksandra
Babic, Goran
Bolevich, Sergey
Issue Date: 2020
Abstract: © 2020, University of Kragujevac, Faculty of Science. All rights reserved. Diabetes mellitus is a major risk factor for cardiovascular diseases, while cardiovascular diseases are a leading cause of morbidity and mortality worldwide. The renin–angiotensin– aldosterone system controls renal, cardiovascular, adrenal function and regulates fluid and electrolyte balance as well as blood pressure. Because of his role, inhibition of renin-angiotensin-aldosteron system is another therapy approach that reduces the risk of diabetes and cardiovascular disease. In this study, our goal was to evaluate effect of valsartan,as inhibitor of angiotensin II receptor type 1, on cardiac tissue and function, with focus on cardiodynamic and oxidative stress. The present study was carried out on 20 adult male Wistar albino rats (8 week old and with body masses of 180-200 g). Rats were divided randomly into 2 groups (10 animals per group). Healthy animals treated with 1 μM of valsartan and streptozotocin-induced diabetic animals perfused with 1 μM of valsartan 4 weeks after the induction of diabetes. Our results demonstrated that acute application of valsartan has different effect on cardiodynamics in rat heart of diabetic and healthy animals but did not improve cardiac function in hy-perglycemia-induced changes. A challenge for further investi-gations are studies with chronic or acute administration, alone or in combination with other angiotensin-converting-enzyme inhibitor in various models of diabetes.
Type: article
DOI: 10.2478/sjecr-2018-0049
ISSN: 1820-8665
SCOPUS: 2-s2.0-85083986635
Appears in Collections:Faculty of Medical Sciences, Kragujevac

Page views(s)




Files in This Item:
File Description SizeFormat 
10.2478_sjecr-2018-0049.pdf668.01 kBAdobe PDFThumbnail

This item is licensed under a Creative Commons License Creative Commons