Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/12791
Title: Galectin-3 in inflammasome activation and primary biliary cholangitis development
Authors: Arsenijevic A.
Stojanovic B.
Milovanovic, Jelena
Arsenijevic D.
Arsenijevic, Nebojsa
Milovanovic, Marija
Journal: International Journal of Molecular Sciences
Issue Date: 2-Jul-2020
Abstract: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Primary biliary cholangitis (PBC) is a chronic inflammatory autoimmune liver disease characterized by inflammation and damage of small bile ducts. The NLRP3 inflammasome is a multimeric complex of proteins that after activation with various stimuli initiates an inflammatory process. Increasing data obtained from animal studies implicate the role of NLRP3 inflammasome in the pathogenesis of various diseases. Galectin-3 is a β-galactoside-binding lectin that plays important roles in various biological processes including cell proliferation, differentiation, transformation and apoptosis, pre-mRNA splicing, inflammation, fibrosis and host defense. The multilineage immune response at various stages of PBC development includes the involvement of Gal-3 in the pathogenesis of this disease. The role of Galectin-3 in the specific binding to NLRP3, and inflammasome activation in models of primary biliary cholangitis has been recently described. This review provides a brief pathogenesis of PBC and discusses the current knowledge about the role of Gal-3 in NLRP3 activation and PBC development.
URI: https://scidar.kg.ac.rs/handle/123456789/12791
Type: article
DOI: 10.3390/ijms21145097
ISSN: 16616596
SCOPUS: 85088680354
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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