Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/12808
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dc.contributor.authorMasnikosa, Romana-
dc.contributor.authorMilutinović, Milan-
dc.contributor.authorCrnolatac, Ivo-
dc.contributor.authorTot, Aleksandar-
dc.contributor.authorVelickovic, Suzana-
dc.contributor.authorBojić-Trbojević, Žanka-
dc.contributor.authorRilak, Ana-
dc.date.accessioned2021-04-20T21:47:04Z-
dc.date.available2021-04-20T21:47:04Z-
dc.date.issued2020-
dc.identifier.issn0162-0134-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/12808-
dc.description.abstract© 2020 Elsevier Inc. Interactions of three Ru(II) chlorophenyl terpyridine complexes: [Ru(Cl-Ph-tpy)(en)Cl]Cl (1), [Ru(Cl-Ph-tpy)(dach)Cl]Cl (2) and [Ru(Cl-Ph-tpy)(bpy)Cl]Cl (3) (Cl-Ph-tpy = 4′-(4-chlorophenyl)-2,2′:6′,2′′-terpyridine, en = 1,2-diaminoethane, dach = 1,2-diaminocyclohexane, bpy = 2,2′-bipyridine) with human serum albumin (HSA), calf thymus DNA and a double-helical oligonucleotide d(CGCGAATTCGCG)2 (1BNA) were examined. Fluorescence emission studies were used to assess the interactions of complexes with HSA, which were of moderate strength for 1 and 2. Molecular docking allowed us to predict mostly π-π stacking and van der Waals interactions between the complexes and the protein. We suggest that the complexes bind to a novel site on HSA, which is different from its druggable sites I, II or III. We suggest a partial intercalation of complexes through the minor groove as a possible mode of interaction with double-helical DNA. Finally, when applied to normal extravillous cell line HTR8/SVneo and JAr choriocarcinoma cell line, complexes 1 and 2 exerted anti-adhesive properties at very low doses, whereas complex 3 had a negligible effect. The obtained results are completion of our studies of Ru(II) terpyridyl complexes that carry N-N ancillary ligands. We suggest a new research direction towards studying the cellular effects of Ru(II) polypyridyl compounds.-
dc.rightsrestrictedAccess-
dc.sourceJournal of Inorganic Biochemistry-
dc.titleAnti-adhesive action of novel ruthenium(II) chlorophenyl terpyridine complexes with a high affinity for double-stranded DNA: in vitro and in silico-
dc.typearticle-
dc.identifier.doi10.1016/j.jinorgbio.2020.111090-
dc.identifier.scopus2-s2.0-85084228536-
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