Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/12809
Title: Sex-related difference in the prognostic value of syncope for 30-day mortality among hospitalized pulmonary embolism patients
Authors: Dzudovic B.
Subotic B.
Novicic N.
Matijasevic J.
Trobok J.
Miric M.
Salinger, Sonja
Stanojevic D.
Nikolić, Maja
Miloradovic, Vladimir
Markovic Nikolic, Natasa
Dekleva M.
Lepojevic Stefanovic D.
Kos L.
Kovacevic Preradovic T.
Obradović I.
Issue Date: 2020
Abstract: © 2020 John Wiley & Sons Ltd Introduction: Recent studies report that syncope is not a significant predictor of 30-day mortality in pulmonary embolism (PE) patients, yet some data suggest sex-related differences may be relevant. Objectives: To evaluate sex-specific prediction significance of syncope for 30-day mortality in PE patients. Methods: A multicentric, retrospective, observational, registry-based study on consecutive PE patients was undertaken. Patients were allocated into either a men or a women group before comparisons were made between patients with syncope and those without syncope. A sex-related prediction of the significance of syncope for 30-day mortality was evaluated. Results: Overall 588 patients [294 (50%) men and 294 (50%) women] were included within the study. Among men, patients with syncope were older and had significantly higher parameters of increased 30-day mortality then patients without syncope. Within the same group, however, difference in the 30-day mortality rate was not significant (log rank P =.942). In contrast to the men, fewer differences in admission characteristics were noticed among women, but those with syncope had significantly increased signs of the right ventricular dysfunction and increased 30-day mortality rate, as compared with those without syncope (log rank P =.025). After adjustment for age in a Cox regression analysis, syncope was a significant predictor of 30-day mortality in women (HR = 2.01, 95%CI 1.02-3.95). Conclusion: Although syncope is associated with other predictors of higher early mortality in both male and female PE patients, only in women it is a significant predictor of 30-day mortality.
URI: https://scidar.kg.ac.rs/handle/123456789/12809
Type: article
DOI: 10.1111/crj.13179
ISSN: 1752-6981
SCOPUS: 2-s2.0-85081717019
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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