Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/12843
Title: Silver(i) complexes with different pyridine-4,5-dicarboxylate ligands as efficient agents for the control of cow mastitis associated pathogens
Authors: Andrejević A.
Dušan M.
Glišić, Biljana
Kljun J.
Stevanović N.
Vojnovic, Sandra
Medić B.
Nikodinovic-Runic, Jasmina
Turel, Iztok
Djuran, Miloš
Issue Date: 2020
Abstract: © The Royal Society of Chemistry 2020. Infections of the cow udder leading to mastitis and lower milk quality are one of the biggest problems in the dairy industry worldwide. Unfortunately, therapeutic options for the treatment of cow mastitis are limited as a consequence of the development of pathogens that are resistant to conventionally used antibiotics. In the search for agents that will be active against cow mastitis associated pathogens, in the present study, five new silver(i) complexes with different chelating pyridine-4,5-dicarboxylate types of ligands, [Ag(NO3)(py-2py)]n(1), [Ag(NO3)(py-2metz)]n(2), [Ag(CH3CN)(py-2py)]BF4(3), [Ag(py-2tz)2]BF4(4) and [Ag(py-2metz)2]BF4(5), py-2py is dimethyl 2,2'-bipyridine-4,5-dicarboxylate, py-2metz is dimethyl 2-(4-methylthiazol-2-yl)pyridine-4,5-dicarboxylate and py-2tz is dimethyl 2-(thiazol-2-yl)pyridine-4,5-dicarboxylate, were synthesized, structurally characterized and assessed forin vitroantimicrobial activity using both standard bioassay and clinical isolates from a contaminated milk sample obtained from a cow with mastitis. These complexes showed remarkable activity against the standard panel of microorganisms and a selection of clinical isolates from the milk of the cow diagnosed with mastitis. With the aim of determining the therapeutic potential of silver(i) complexes, their toxicityin vivoagainst the model organism,Caenorhabditis elegans(C. elegans), was investigated. The complexes that had the best therapeutic profile,2and5, induced bacterial membrane depolarization and the production of reactive oxygen species (ROS) inCandida albicanscells and inhibited the hyphae as well as the biofilm formation. Taken together, the presented data suggest that the silver(i) complexes with pyridine ligands could be considered for the treatment of microbial pathogens, which are causative agents of cow mastitis.
URI: https://scidar.kg.ac.rs/handle/123456789/12843
Type: article
DOI: 10.1039/d0dt00518e
ISSN: 1477-9226
SCOPUS: 2-s2.0-85084694295
Appears in Collections:Faculty of Science, Kragujevac

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