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Authors: Antonijević, Marko
Simijonović, Dušica
Kesić, Ana
Avdović, Edina
Markovic, Zoran
Issue Date: 2021
Abstract: Coumarins are a widespread group of compounds. They have a wide range of physiological effects, from antifungal, through anticoagulant to anticancer, and therefore they have found wide application in the treatment of various diseases. In this paper, the ability of 4-hydroxy-3-methoxy-N'-((E)-1-(2,4-dioxo-2H-chromen- 3(4H)-ylidene)ethyl)benzohydrazide to inactivate ROS was investigated. The analysis of the obtained results showed that the SET-PT (Single Electron Transfer Followed By Proton Transfer) mechanism is non-operative. On the other hand, the thermodynamic parameters describing the HAT *Hydrogen Atom Transfer) and the first step of the SPLET (Sequential Proton Loss-Electron Transfer) mechanism indicate that both mechanisms will be operative. The antiradical capacity of the test compound with the radicals decreases in the following order: •OH> •OCH3> •OC(CH3)3> •OOH> •OOCH3> •OOCH2CH3.
Type: conferenceObject
DOI: 10.46793/SBT26.423A
Appears in Collections:Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac

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