Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/13235
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dc.rights.licenseBY-NC-ND-
dc.contributor.authorCincović, Marko-
dc.contributor.authorĐoković, Radojica-
dc.contributor.authorBelić, Branislava-
dc.contributor.authorLakić, Ivana-
dc.contributor.authorStojanac, Nenad-
dc.contributor.authorStevančević, Ognjen-
dc.contributor.authorStaničkov, Nenad-
dc.date.accessioned2021-05-29T21:16:16Z-
dc.date.available2021-05-29T21:16:16Z-
dc.date.issued2018-
dc.identifier.citationCincović, M. R., Đoković, R., Belić, B., Lakić, I., Stojanac, N., Stevančević, O., & Staničkov, N. [2018]. Insulin resistance in cows during the periparturient period (review). Acta agriculturae Serbica, 23(46), 233-245.en_US
dc.identifier.issn0354-9542en_US
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/13235-
dc.description.abstractInsulin resistance is a state in which the biological effect of insulin is reduced when its concentration decreases or when a compensatory mechanism increases its concentration. Insulin resistance is characterized by reduced insulin response to glucose, i.e. decreased pancreatic beta cell function (insulin hyporesponsiveness) and/or reduced sensitivity of glucose to insulin (reduced intake of glucose by peripheral tissues under the influence of insulin - eng. insulin sensitivity). Methods for estimating insulin resistance include direct methods (hyperinsulinaemic-euglycaemic clamp, golden standard), indirect methods (intravenous glucose tolerance test) and surrogate methods (indices calculated from basal concentrations of insulin, glucose, NEFA and BHB-HOMA, QUICKI, RQUICKI and RQUICKI- BHB). Surrogate indices show correlations with direct and indirect test results but they are inconsistent. Inconsistency occurs because the dependence of glucose concentrations on the degree of hepatic gluconeogenesis should be kept in mind when evaluating insulin resistance in ruminants. Therefore, the hyperinsulinaemic-euglicaemic clamp method is particularly suitable as it excludes gluconeogenesis in hepatocytes from analysis. Our results have shown a correlation between HOMA, QUICKI and RQUICKI indices and metabolic profile parameters. The correlation between dynamic and basal responses of NEFA, BHB, insulin, glucose and inorganic phosphorus is significantly dependent on RQUICKI-BHB index values in ketotic cows. RQUICKI index of insulin resistance is substantially dependent on NEFA values in early lactation as well as on insulin and glucose values in the dry period. Further investigations should focus on the practical evaluation of the use of insulin resistance indices.en_US
dc.language.isoenen_US
dc.publisherUniversity of Kragujevac - Faculty of Agronomy, Čačaken_US
dc.relationImprovement of productivity and welfare of dairy cows by indentification and exclusion of stress factors (MESTD - 31062)en_US
dc.relationProduction of hard cheese with added value from milk produced in organic conditions and self-sustainable systems (MESTD - 31095)en_US
dc.rightsopenAccess-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.sourceActa agriculturae Serbicaen_US
dc.subjectinsulin resistance indicesen_US
dc.subjectmetabolic stressen_US
dc.subjectcowsen_US
dc.subjectearly lactationen_US
dc.titleInsulin resistance in cows during the periparturient period (review)en_US
dc.title.alternativeINSULINSKA REZISTENCIJA KOD KRAVA U PERIPARTALNOM PERIODU (PREGLED)en_US
dc.typereviewen_US
dc.description.versionPublisheden_US
dc.identifier.doi10.5937/AASer1846233Cen_US
dc.type.versionPublishedVersionen_US
Appears in Collections:Faculty of Agronomy, Čačak

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