Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/13442
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dc.rights.licenseBY-NC-ND-
dc.contributor.authorMilovanović, Vesna-
dc.contributor.authorPetrović, Zorica-
dc.contributor.authorPetrović, Vladimir-
dc.contributor.authorSimijonović, Dušica-
dc.contributor.authorMladenović, Milan-
dc.contributor.authorTomaševic, Nevena-
dc.contributor.authorČomić, Ljiljana-
dc.contributor.authorRadojevic, Ivana-
dc.date.accessioned2021-07-16T11:03:03Z-
dc.date.available2021-07-16T11:03:03Z-
dc.date.issued2021-
dc.identifier.citationMilovanović, V. M., Petrović, Z. D., Petrović, V. P., Simijonović, D., Mladenović, M., Tomašević, N., Čomić, L. R., & Radojević, I. D. [2021]. In vitro and in silico lipoxygenase inhibition studies and antimicrobial activity of pyrazolyl-phthalazine-diones. Kragujevac Journal of Science, (43), 35-52.en_US
dc.identifier.issn1450-9636en_US
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/13442-
dc.description.abstractThe series of pyrazolyl-phthalazine-dione derivatives (PPDs) was subjected to evaluation of their in vitro lipoxygenase (LOX) inhibition and antimicrobial activities. Results obtained for LOX inhibition activities of PPDs showed that all compounds exhibit good to excellent activity, whereby compounds with eudesmic, syringic, vanillic or toluic moiety are the most active. Molecular modelling study was performed to investigate the possible mechanism of action and binding mode of compounds within the LOX active site. Docking results revealed that activity of the examined compounds depends on the functional group ability to create hydrogen bond accepting (HBA) and hydrophobic features (Hy) in the LOX-Ib active site. In addition, all substances were tested for their antibacterial and antifungal activities. The investigated compounds showed better antifungal than antibacterial activity. The highest antifungal activity was on Aspergillus fumigatus ATTC 204305 and Trichoderma viridae ATCC 13233.en_US
dc.language.isoenen_US
dc.publisherUniversity of Kragujevac, Faculty of Scienceen_US
dc.relationMinistry of Education, Science and Technological Development, Republic of Serbia (Institution: University of Kragujevac, Faculty of Science) (MESTD - 451-03-68/2020-14/200122)en_US
dc.relationMinistry of Education, Science and Technological Development, Republic of Serbia (Institution: Institute of Information Technology) (MESTD - 451-03-68/2020-14/200378)en_US
dc.rightsopenAccess-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.sourceKragujevac Journal of Scienceen_US
dc.subjectpyrazolyl-phthalazine-dione derivativesen_US
dc.subjectanti-inflammatory activityen_US
dc.subjectmolecular dockingen_US
dc.subjectantimicrobial activityen_US
dc.titleIn vitro and in silico lipoxygenase inhibition studies and antimicrobial activity of pyrazolyl-phthalazine-dionesen_US
dc.typearticleen_US
dc.description.versionPublisheden_US
dc.identifier.doi10.5937/KgJSci2143035Men_US
dc.type.versionPublishedVersionen_US
Appears in Collections:Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac

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