Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/13510
Title: The oxidative stress parameters as useful tools in evaluating the dna damage and changes in the complete blood count in hospital workers exposed to low doses of antineoplastic drugs and ionizing radiation
Authors: Mrdjanovic J.
Šolajić S.
Srdjenovic Conic, Branislava
Bogdanovic V.
Karaba-Jakovljevic D.
Kladar, Nebojša
Jurisic, Vladimir
Issue Date: 2021
Abstract: Hospital workers at the Oncology Department are occupationally exposed to antineo-plastic drugs (ANTNP) or low doses of ionizing radiation (Irrad). Therefore, the aim of this study was to evaluate the level of DNA damage, the oxidative stress parameters and complete blood count (CBC) of hospital workers in order to analyze the negative health effects of ANTNP and low dose Irrad. The frequency of micronuclei (MN) and proliferation index (PI) were analyzed by cytokinesis-block test. The oxidative stress biomarkers evaluated were the level of lipid peroxidation in plasma and catalase activity (CAT) in erythrocytes. A group of 86 hospital workers (35 exposed to ANTPN and 51 to Irrad) had increased MN frequency, CAT activity and level of lipid peroxidation compared to the control group, which consisted of 24 volunteers. The hemoglobin level was lower in the ANTNP group compared to thecontrol group, while a significant difference in RBC was rec-orded between thecontrol and Irrad groups, and in platelet count betweentheIrrad and ANTNP group. The results showed increased DNA damage, oxidative stress parameters, as well as impair-ment on complete blood count in hospital workers occupationally exposed to antineoplastic drugs and low-dose ionizing radiation. As this research has shown the importance of oxidative stress, we suggest that in addition to routine methods in periodic medical evaluation, the possibility of apply-ing oxidative stress parameters is considered. Moreover, hospital workers exposed to ANTNP and Irrad in the workplace should undergo not only a more complete health prevention procedure but also have a more appropriate health promotion.
URI: https://scidar.kg.ac.rs/handle/123456789/13510
Type: article
DOI: 10.3390/ijerph18168445
ISSN: 1661-7827
SCOPUS: 2-s2.0-85112114580
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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