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https://scidar.kg.ac.rs/handle/123456789/13571
Назив: | Effects of galectin-1 on immunomodulatory properties of human monocyte-derived dendritic cells |
Аутори: | Dzopalic, Tanja Kostić, Miloš Kostic M. Marjanović, Goran Guzina J. Jurisic, Vladimir Božić Nedeljković B. |
Датум издавања: | 2021 |
Сажетак: | Our study aimed to evaluate the effects of Gal-1 in dose depending manner on maturation and immunomodulatory properties of monocyte-derived (Mo) DCs in-vitro. The effects were analyzed by monitoring their phenotypic characteristics, cytokine profile, and the ability to direct the immune response in the co-culture with allogeneic CD4+T cells. Gal-1 reduced the expression of CD80 and CD86 molecules on MoDCs compared to untreated MoDCs. Gal-1 at concentrations of 1 and 6 μg/mL significantly reduced IL-12 production, while the concentration of 3 μg/mL led to its significant increase. Gal-1 in all concentrations induced a significant increase in the production of IL-10. Treatment of MoDCs with 3 and 6 μg/mL of Gal-1 stimulated the production of IL-2 and IFN-γ in the co-culture with CD4+T lymphocytes. This study demonstrated a dual immunomodulatory effect of Gal-1 on MoDCs in terms of immune stimulation and immune suppression, depending on the applied concentration. |
URI: | https://scidar.kg.ac.rs/handle/123456789/13571 |
Тип: | article |
DOI: | 10.1080/08977194.2021.1947267 |
ISSN: | 0897-7194 |
SCOPUS: | 2-s2.0-85109737822 |
Налази се у колекцијама: | Faculty of Medical Sciences, Kragujevac |
Датотеке у овој ставци:
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PaperMissing.pdf Ограничен приступ | 29.86 kB | Adobe PDF | Погледајте |
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