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Назив: Effects of galectin-1 on immunomodulatory properties of human monocyte-derived dendritic cells
Аутори: Dzopalic, Tanja
Kostić, Miloš
Kostic M.
Marjanović, Goran
Guzina J.
Jurisic, Vladimir
Božić Nedeljković B.
Датум издавања: 2021
Сажетак: Our study aimed to evaluate the effects of Gal-1 in dose depending manner on maturation and immunomodulatory properties of monocyte-derived (Mo) DCs in-vitro. The effects were analyzed by monitoring their phenotypic characteristics, cytokine profile, and the ability to direct the immune response in the co-culture with allogeneic CD4+T cells. Gal-1 reduced the expression of CD80 and CD86 molecules on MoDCs compared to untreated MoDCs. Gal-1 at concentrations of 1 and 6 μg/mL significantly reduced IL-12 production, while the concentration of 3 μg/mL led to its significant increase. Gal-1 in all concentrations induced a significant increase in the production of IL-10. Treatment of MoDCs with 3 and 6 μg/mL of Gal-1 stimulated the production of IL-2 and IFN-γ in the co-culture with CD4+T lymphocytes. This study demonstrated a dual immunomodulatory effect of Gal-1 on MoDCs in terms of immune stimulation and immune suppression, depending on the applied concentration.
URI: https://scidar.kg.ac.rs/handle/123456789/13571
Тип: article
DOI: 10.1080/08977194.2021.1947267
ISSN: 0897-7194
SCOPUS: 2-s2.0-85109737822
Налази се у колекцијама:Faculty of Medical Sciences, Kragujevac

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