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Title: Association between oral contraceptive use and pancreatic cancer risk: A systematic review and meta-analysis
Authors: Ilic, Milena
Milicic, Biljana
Ilic, Irena
Issue Date: 2021
Abstract: BACKGROUND Studies on the association of oral contraceptive (OC) use and pancreatic cancer showed inconsistent findings. AIM To evaluate the relationship between OC use and pancreatic cancer risk. METHODS A literature search for observational studies (case-control and cohort studies) was conducted up to December 2020. A meta-analysis was performed by calculating pooled relative risks (RRs) and 95% confidence intervals (CIs). Heterogeneity was assessed using Cochran's chi-square test and I2 statistic. Subgroup analyses were performed by study design, source of controls in case-control studies, number of cases of pancreatic cancers, study quality according to Newcastle-Ottawa Scale score, geographical region and menopausal status. All analyses were performed using Review Manager 5.3 (RevMan 5.3). RESULTS A total of 21 studies (10 case-control studies and 11 cohort studies) were finally included in the present meta-analysis, comprising 7700 cases of pancreatic cancer in total. A significant association was observed between the ever use of OC and pancreatic cancer risk in the overall analysis (RR = 0.85; 95%CI = 0.73-0.98; P = 0.03). Duration of OC use (< 1 year, < 5 years, 5-10 years, > 10 years) was not significantly associated with the risk of pancreatic cancer. Subgroup analyses revealed a statistically significant subgroup difference for the geographic region in which the study was conducted (Europe vs Americas vs Asia; P = 0.07). Subgroup analyses showed a statistically significant decrease in pancreatic cancer risk and OC use in high-quality studies, studies conducted in Europe, and in postmenopausal women. CONCLUSION Despite the suggested protective effects of OC use in this meta-analysis, further epidemiological studies are warranted to fully elucidate the association between the use of OC and pancreatic cancer risk.
Type: review
DOI: 10.3748/wjg.v27.i20.2643
ISSN: 1007-9327
SCOPUS: 2-s2.0-85106389698
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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