Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/13697
Title: The electrophysiological effects of cadmium on Retzius nerve cells of the leech Haemopis sanguisuga
Authors: Jovanovic, Zorica
Issue Date: 2021
Abstract: Cadmium is considered one of the most toxic heavy metals which can cause cytotoxicity in multiple organs including the brain. Despite many studies over the past decades, the cellular and molecular mechanisms underlying its neurotoxicity remain unclear. The present study was designed to examine the acute effects of cadmium chloride (CdCl2) on the electrical activity of the Retzius nerve cells of leech Haemopis sanguisuga using electrophysiological techniques. CdCl2, in concentrations of 10–100 μM, produced a dose- and time-dependent depolarization of Retzius neurons, paralleled by an increase in firing frequency and action potential duration. To examine potential mechanisms, we studied the effects of cadmium on the outward potassium current upon depolarization using a point microelectrode voltage-clamp technique. Reduction of the fast, and partial inhibition of the slow outward current were observed after adding 50 and 100 μM CdCl2 in the external fluid. The present results support the view that the effect of cadmium on the outward potassium channel may be a potential contributing mechanism for cadmium-induced neurotoxic damage. The proposed mechanism of cadmium action on the electrical properties of leech Retzius neurons might have broader significance concerning not only the leeches but vertebrate brains as well.
URI: https://scidar.kg.ac.rs/handle/123456789/13697
Type: article
DOI: 10.1016/j.cbpc.2021.109062
ISSN: 1532-0456
SCOPUS: 2-s2.0-85104918945
Appears in Collections:Faculty of Medical Sciences, Kragujevac

Page views(s)

380

Downloads(s)

7

Files in This Item:
File Description SizeFormat 
PaperMissing.pdf
  Restricted Access
29.86 kBAdobe PDFThumbnail
View/Open


Items in SCIDAR are protected by copyright, with all rights reserved, unless otherwise indicated.